We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
Most Useful Reviews
9
Eases bone pain
58 people found this helpful
An effective and budget-friendly drug! I was impressed by the quality of this magnesium. The capsules are easy to swallow, with no unpleasant smell or taste. It provides an excellent relaxing effect; I noticed my muscle relaxation immediately. My sleep quality significantly improved, and my previous knee pain disappeared while taking magnesium.
Read More
9
Magic for bone pain
41 people found this helpful
More than wonderful! Magnesium is a way to relax the body and induces rapid sleep. It significantly relieved my joint pain, easing the discomfort during my menstrual period. I sincerely recommend magnesium for treating joint pain, cramps, and overall relaxation.
Read More
7.5
Relieves bone and muscle pain
27 people found this helpful
Magnesium malate is fantastic for energy production and supporting the nervous system. I found it highly effective for both my bone and muscle pain, having tried many other types with no benefit before. This particular brand has excellent quality.
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
Read More
7
Pamidronate therapy reduces bone pain
New trends in the treatment of osteogenesis imperfecta type III - own experience.
We evaluated the effects of pamidronate therapy on children with osteogenesis imperfecta type III. Over the course of treatment, we saw reductions in bone pain, alongside a significant decrease in fracture incidence.
The therapy positively impacted children's daily activities and their overall mobility. Importantly, the treatment was found to be safe, although some patients experienced mild side effects like low calcium levels and a fever. Overall, our findings suggest that bisphosphonate therapy is beneficial for management in these young patients.
Read More
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
Read More
User Reviews
USERS' SCORE
Good
Based on 50 Reviews
8.1
All Reviews
Positive Reviews
Negative Reviews
9
Eases bone pain
58 people found this helpful
An effective and budget-friendly drug! I was impressed by the quality of this magnesium. The capsules are easy to swallow, with no unpleasant smell or taste. It provides an excellent relaxing effect; I noticed my muscle relaxation immediately. My sleep quality significantly improved, and my previous knee pain disappeared while taking magnesium.
Read More
9
Magic for bone pain
41 people found this helpful
More than wonderful! Magnesium is a way to relax the body and induces rapid sleep. It significantly relieved my joint pain, easing the discomfort during my menstrual period. I sincerely recommend magnesium for treating joint pain, cramps, and overall relaxation.
Read More
7.5
Relieves bone and muscle pain
27 people found this helpful
Magnesium malate is fantastic for energy production and supporting the nervous system. I found it highly effective for both my bone and muscle pain, having tried many other types with no benefit before. This particular brand has excellent quality.
Read More
9
Leg cramps gone
11 people found this helpful
I sleep so well! Our family takes this at night, and we've noticed no more leg cramps or pain waking us up. Since magnesium doesn鈥檛 accumulate in the body, we can safely take it regularly.
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9
Alleviates joint pain
9 people found this helpful
An essential mineral! Magnesium is involved in over 300 enzymatic reactions and aids in calcium fixation within bones. It has significantly reduced my joint and muscle pain and helped ease my training fatigue. I also recommend it for those with fibromyalgia.
Bone pain is a discomfort or ache that originates within the bones themselves and can range from mild to severe. It is different from muscle or joint pain, as it directly affects the skeletal structure. Bone pain can be caused by a variety of factors, including injuries, medical conditions such as osteoarthritis or osteoporosis, infections, or tumors. Symptoms may vary depending on the underlying cause but often include a dull, penetrating ache that may worsen with movement or pressure.
If you're experiencing persistent bone pain, it鈥檚 essential to consult with a healthcare professional for a proper diagnosis and treatment plan. Imaging tests like X-rays, MRI, or CT scans may be utilized to determine the root cause of the pain. Treatment can vary widely, ranging from medications to alleviate pain and inflammation to physical therapy or, in some cases, surgical interventions. Understanding the underlying cause is crucial to effectively managing bone pain and ensuring the best path to recovery.
Magnesium is a chemical element with the symbol Mg and atomic number 12. It is a lightweight, silvery-white metal that is a member of the alkaline earth metals group. Often classified as one of the most abundant elements in the Earth's crust, magnesium plays a crucial role in various biological functions and is essential for living organisms. In nature, magnesium can be found in large quantities, primarily in minerals such as dolomite and magnesite, and it is also present in seawater.
In terms of health benefits, magnesium is vital for numerous metabolic processes, including energy production, DNA synthesis, and muscle function. It contributes to bone health, helps regulate blood pressure, and supports bone formation by promoting the effects of vitamin D. The recommended dietary allowance (RDA) for magnesium varies by age and gender, but it is generally important to include magnesium-rich foods like leafy greens, nuts, seeds, and whole grains in your diet to ensure adequate intake. For those who may not receive enough magnesium through their diet alone, supplements are also available; however, it is advisable to consult a healthcare professional before starting any supplementation.
Magnesium plays a crucial role in bone health and may help alleviate some types of bone pain, especially if the pain is related to deficiencies. This essential mineral aids in the regulation of calcium levels in the bone, which is vital for maintaining bone density and overall strength. Some studies have suggested that adequate magnesium intake may reduce the risk of osteoporosis and bone fractures, which are common causes of long-term bone pain. However, if you are experiencing significant or persistent bone pain, it's crucial to consult with a healthcare professional to identify the underlying cause.
While magnesium may provide support for bone health, it should not be viewed as a standalone treatment for bone pain. Incorporating magnesium-rich foods, such as leafy greens, nuts, seeds, and whole grains, can be beneficial in supporting bone health. For some individuals, magnesium supplements may also be considered, but it's important to do this under medical supervision to avoid potential side effects or interactions with other medications. Additionally, a comprehensive approach that includes proper nutrition, exercise, and other lifestyle factors is essential for managing bone health effectively.
Based on user reviews, the time it typically takes to see results from taking magnesium supplements for bone pain can vary. Many users report feeling noticeable improvements within a few days to a couple of weeks. For instance, one user mentioned significant pain reduction after about four days of use Read Review. Another review highlighted remarkable relief of joint pain and inflammation after just two weeks Read Review.
Additionally, some users have experienced more gradual improvements, such as after a three-month course where they noted enhanced sleep and relief from muscle pain Read Review. Overall, while immediate relief can be possible, a consistent intake over weeks might be necessary for optimal benefits, especially for chronic conditions.
This supplement shows some promise in alleviating bone pain, particularly for specific conditions. Research has indicated that magnesium-based treatments may aid in managing pain linked to osteoporosis. One study developed a drug delivery system that combines magnesium with denosumab, demonstrating potential for biocompatibility and promoting bone formation. However, it highlighted the need for further studies to confirm its effectiveness in real-world scenarios [1].
Furthermore, findings from another study on choline magnesium trisalicylate (CMT) suggest it may help reduce bone pain in cancer patients. In a trial involving participants with metastatic cancer, a significant pain reduction was observed shortly after treatment with CMT. Although this points to its potential efficacy, the study noted that further investigation is needed to determine its overall effectiveness in bone pain management [3]. Therefore, while there is scientific support for magnesium-related supplements in addressing bone pain, more extensive and conclusive studies are required to establish their definitive role.
Users have reported a range of improvements in their symptoms after taking magnesium supplements, especially with regard to pain relief, sleep quality, and muscle relaxation. Many individuals noted an immediate relaxing effect on their muscles and enhanced sleep quality. For example, one user experienced a significant reduction in knee pain and improved sleep shortly after starting magnesium Read Review. Another reviewer highlighted marked relief from joint pain and menstrual discomfort after using magnesium, emphasizing its effectiveness for relaxation and pain management Read Review.
Others attested to the cumulative benefits of consistent use, with one individual reporting that after a few months of daily supplementation, his muscle pain and eye twitching had disappeared Read Review. Additional anecdotal evidence suggests that magnesium supplements can help significantly reduce chronic pain linked to conditions like fibromyalgia and joint issues Read Review. Overall, while the experiences of these users indicate that magnesium supplementation can lead to substantial improvements, it's important to note that individual results may vary.
Users reported positive experiences when combining magnesium supplements with other forms of magnesium to help manage bone pain and related symptoms. For instance, one user noted that they take magnesium malate in the morning for energy and muscle relaxation and magnesium glycinate in the evening, which successfully alleviated cramps and muscle pain while also improving sleep quality Read Review. Another individual emphasized that they found substantial relief from joint pain by using magnesium malate, and described its benefits as transformative, suggesting it could be effective in conjunction with other magnesium types Read Review.
Additionally, several reviews highlighted the potential synergy between magnesium and other supplements. For example, one user mentioned taking magnesium alongside another supplement to optimize health benefits, which resulted in a noted decrease in joint pain Read Review, while another described how their overall well-being improved with consistent magnesium use alongside other health practices Read Review. Users generally seemed to find that such combinations of magnesium forms could lead to enhanced effectiveness in managing pain and promoting better sleep and relaxation.
While the exact optimal dose of magnesium for treating bone pain has not been definitively established in the research, one study did explore the use of choline magnesium trisalicylate (CMT) in alleviating bone pain. In a clinical trial involving 26 participants with metastatic cancer, CMT demonstrated a significant reduction in pain just one hour after treatment, suggesting its potential for managing bone pain [3]. However, the research indicates that further studies are necessary to fully gauge its effectiveness.
Additionally, another research project highlighted the beneficial role of magnesium ions in the context of osteoporosis treatment, implying that magnesium could support bone formation and possibly alleviate associated pain [1]. Given these insights, while no precise dosage is outlined, magnesium appears to have a supportive role in pain management strategies, particularly when combined with other treatments. For best results, consulting with a healthcare provider for personalized recommendations based on individual health needs and conditions is key.
7.5
Effective solution
5 people found this helpful
I鈥檓 grateful for this product, which has high quality. After about four days of taking it, my pain significantly reduced. I initially started with a high dose for my neck and shoulder pain, then settled into a comfortable routine. I鈥檓 very pleased with the results.
9
Joint pain miracle
1 people found this helpful
Great product! After just two weeks of use, it has worked wonders for relieving joint pain and inflammation.
9
Effective benefits
After completing a three-month course, I found it helped with my sleep, and the muscle pain and eye twitching disappeared. Honestly, I benefited greatly from it. I took two pills daily, one upon waking and the other before bed.
9
Eases bone pain
58 people found this helpful
An effective and budget-friendly drug! I was impressed by the quality of this magnesium. The capsules are easy to swallow, with no unpleasant smell or taste. It provides an excellent relaxing effect; I noticed my muscle relaxation immediately. My sleep quality significantly improved, and my previous knee pain disappeared while taking magnesium.
9
Magic for bone pain
41 people found this helpful
More than wonderful! Magnesium is a way to relax the body and induces rapid sleep. It significantly relieved my joint pain, easing the discomfort during my menstrual period. I sincerely recommend magnesium for treating joint pain, cramps, and overall relaxation.
9
Transformative for pain
9 people found this helpful
"Revitalize Your Life with NOW Foods Magnesium Malate" has been pivotal in combating insomnia, headaches, and chronic fatigue. Since using it, my sleep quality has greatly improved, and it has significantly reduced my fibromyalgia-related pain. I highly recommend it as a natural remedy that has transformed my life.
10
Family benefits
2 people found this helpful
Magnesium malate is an excellent form of magnesium that my family takes during the day. In the evening, I provide the children with magnesium glycinate. I've noticed that cramps and muscle pain have disappeared, and my sleep has improved as well. For those suffering from constipation, magnesium citrate is preferable. We have been using it for our family for 1.5 months now, and the packaging is convenient with good dosages.
9
Improved bone pain
48 people found this helpful
For me, this is the best form of magnesium; it aids my sleep greatly, and I no longer suffer from joint pain. I feel an improvement in my muscles, and I find my gym sessions easier. I take 2 capsules daily alongside Magtein for optimal body and mind health.
7.5
Pain reduction
7 people found this helpful
I highly recommend these for my CFS/ME. After taking 3 tablets daily, I observed a significant decrease in all pain, improved sleep, and no more muscle twitching. A month in, I still experience these improvements with zero side effects. It鈥檚 challenging to get enough magnesium from food alone, so I鈥檒l likely continue using these forever.
7
Promising drug delivery for osteoporosis
Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis.
We developed a novel drug delivery system combining denosumab and magnesium within metal-organic frameworks to target osteoarthritis. The framework showed good potential for loaded drug release, delivering about 72% of denosumab in just 8 hours.
Additionally, it released magnesium ions, which are beneficial for bone formation. Our cytotoxicity tests demonstrated that the system is biocompatible and encourages cell growth over time. While our findings are promising for pain relief linked to osteoporosis, further studies are needed to confirm effectiveness in real-world scenarios.
7
CMT shows potential for pain relief
The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study.
We investigated how choline magnesium trisalicylate (CMT) helps alleviate bone pain in patients with metastatic cancer. In a carefully designed study involving 26 participants, we compared CMT against a placebo in a crossover format, measuring pain relief at multiple intervals after dosing.
While we observed a significant reduction in pain just one hour post-treatment with CMT, other comparisons showed improvements that didn't reach statistical significance. This suggested that CMT might assist in managing bone pain, potentially complementing traditional opioids, but overall effectiveness is still under exploration.
References
Alsaikhan F, Mahmoud MZ, Suliman M. Synthesis and characterization of novel denosumab/magnesium-based metal organic frameworks nanocomposite prepared by ultrasonic route as drug delivery system for the treatment of osteoporosis. Front Bioeng Biotechnol. 2023;11:1153969. 10.3389/fbioe.2023.1153969
Jakubowska-Pietkiewicz E, Chlebna-Sok贸艂 D. New trends in the treatment of osteogenesis imperfecta type III - own experience. Ortop Traumatol Rehabil. 2008;10:593.
Johnson JR, Miller AJ. The efficacy of choline magnesium trisalicylate (CMT) in the management of metastatic bone pain: a pilot study. Palliat Med. 1994;8:129.